Antiangiogenic Agents in Combination with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer

Most patients with non-small cell lung cancer (NSCLC) present with advanced disease requiring systemic chemotherapy. Treatment with the antiangiogenic agent bevacizumab in combination with standard platinum-based doublet chemotherapy has been shown to improve outcomes in patients with advanced NSCLC. Several multitargeted antiangiogenic tyrosine kinase inhibitors (e.g., sorafenib, sunitinib, cediranib, vandetanib, BIBF 1120, pazopanib, and axitinib) are also being evaluated in combination with standard chemotherapy. Here we review current clinical data with combination therapy involving antiangiogenic agents and cytotoxic chemotherapy in patients with advanced NSCLC

Large-scale unit commitment under uncertainty: an updated literature survey

The Unit Commitment problem in energy management aims at finding the optimal production schedule of a set of generation units, while meeting various system-wide constraints. It has always been a large-scale, non-convex, difficult problem, especially in view of the fact that, due to operational requirements, it has to be solved in an unreasonably small time for its size. Recently, growing renewable energy shares have strongly increased the level of uncertainty in the system, making the (ideal) Unit Commitment model a large-scale, non-convex and uncertain (stochastic, robust, chance-constrained) program. We provide a survey of the literature on methods for the Uncertain Unit Commitment problem, in all its variants. We start with a review of the main contributions on solution methods for the deterministic versions of the problem, focussing on those based on mathematical programming techniques that are more relevant for the uncertain versions of the problem. We then present and categorize the approaches to the latter, while providing entry points to the relevant literature on optimization under uncertainty. This is an updated version of the paper "Large-scale Unit Commitment under uncertainty: a literature survey" that appeared in 4OR 13(2), 115--171 (2015); this version has over 170 more citations, most of which appeared in the last three years, proving how fast the literature on uncertain Unit Commitment evolves, and therefore the interest in this subject

The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Mesoproterozoic rifting and Pan-African continental collision in SE India: evidence from the Khariar alkaline complex

The suture zone between the Bhandara craton and the granulite-facies rocks of the Eastern Ghats Province in SE India contains a number of deformed alkaline and tholeiitic intrusives. The Khariar alkaline complex is one of the several occurrences which intruded in the Mesoproterozoic (1,48017 Ma, 2r) and was deformed during the Pan-African tectonothermal event. The geochemical signatures indicate a rift-related setting for the magmatic activity. The nepheline syenite parent magma may have been produced by in-mantle fractionation of clinopyroxene and Ti-rich amphibole from a basanitic primary magma derived from an enriched spinel lherzolite mantle source in the sub-continental lithosphere. Geochemical variations in the Khariar alkaline suite can be modeled by the fractionation of clinopyroxene, amphibole, titanite, zircon, apatite and allanite. The Mesoproterozoic alkaline magmatism at Khariar marks the initiation of a NE-SW rift which formed several craton margin basins and opened an ocean towards the south. The sediments of the cratogenic basins and the Eastern Ghats Province were deposited in these rift-related basins. A K-Ar age of 1,33053 Ma from glauconites in sandstone suggests that the NW-SE trending Godavari-Pranhita graben formed at approximately the same time as the rift at the craton margin. If the two are related, the Godavari-Pranhita graben may represent the failed arm of a rift system in which the NE-SW arm was the active segment. The granulite-facies deformation and metamorphism of the Eastern Ghats Province sediments may be related to an episode of Grenvillian basin inversion. The Mesoproterozoic rifting and Grenvillian basin closure may thus represent two well-defined parts of a Wilson cycle i.e. the opening and closure of an ocean. The Khariar and other alkaline bodies were, however, deformed during a Pan-African collisional event associated with the westward thrusting of the Eastern Ghats Province granulites over the cratonic foreland